We are interested in understanding adult neurogenesis in normal and perturbed scenario such as hyperglycemia. Neurons love glucose but there is fine balance between the love – hate relationship of glucose concentration in brain. Our research focuses in identifying the role of glucose in adult neuritogenesis. Decoding mechanisms underlying neuritogenesis from adult central nervous system (CNS), Brain and Retina, will let us identify mechanisms of protein misfolding in increased glucose conditions. Recent research shows, increased glucose concentrations result in protein misfolding leading to neurodegenerative disorders (NDD).

Few fundamental questions that arise from the current literature are like Who are the functional partners modulating this? Which signaling pathways are engaged in this phenomenon? Are . Signaling pathways such as Notch is engaged in developing brain? The components of Notch pathway re-appear as a maintenance pathway at the later stages of life.

It is intriguing to understand how this pathway functions in adult CNS particularly in altered conditions, such as, impaired glucose metabolism. From our findings, we expect to provide significant new insights into the complex mechanisms of neurite formation and regulation, with implications for the development of neurons and subsequently neurodegeneration. By mapping their similarities and dissimilarities we will find a common mechanism regulating adult neuritogenesis and subsequent growth cone formation and synapse formation in central nervous system.